IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
نویسندگان
چکیده
منابع مشابه
Pathogenesis of psoriasis and psoriatic arthritis
Pathophysiology of psoriasis The pathophysiology of psoriasis is multifaceted and dynamic, involving a complex interplay between constitutive cells of the skin and the innate and adaptive immune systems. Until the early 1980s, psoriasis was considered to be primarily a disease of epidermal keratinocyte proliferation, with the cutaneous inflammatory infiltrate a secondary consequence [1]. Howeve...
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In this issue of The Journal, Madland, et al report results of a 2 week pilot study on a dietary supplementation with seal oil compared to soy oil in patients with psoriatic polyarthritis1. Despite its short duration, several results of this research are significant. Mainly, 4 weeks after the treatment, subjects taking seal oil dietary supplementation reported improvement in patient’s global as...
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Psoriasis and psoriatic arthritis (PsA) are interrelated disorders, as most patients with PsA also have psoriasis. Thus it is not surprising that epidemiological and immunogenetic studies have uncovered important links between these two disorders. Both disorders are highly heritable, and the prevalence of psoriasis is 19 times higher among first degree relatives of probands with PsA compared wi...
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Psoriatic arthritis is a complex disease affecting primarily peripheral and axial joints and entheses together with the skin. The pathogenesis is characterized by a genetic background and by inflammatory mechanisms which may be triggered by environmental factors. Several susceptibility genes have been investigated; they include HLA genes, genes within the HLA region and genes outside the HLA re...
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Psoriatic arthritis (PsA) is characterised by several unique clinical features that differentiate it from rheumatoid arthritis (RA). Attempts to identify immunopathological mechanisms, some shared with psoriasis, that underlie these differences from RA have been most challenging. Recent research studies, however, highlight novel findings in PsA at the molecular, cellular, and tissue levels that...
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ژورنال
عنوان ژورنال: Medical Immunology (Russia)
سال: 2014
ISSN: 2313-741X,1563-0625
DOI: 10.15789/1563-0625-2014-2-127-138